Cocaine Dependence Differences in Men and Women


The latest brain imaging research shows that stress strongly activates parts of the brain linked to craving in women with cocaine dependence, whilst drug cues trigger similar parts of the brain in men with cocaine dependence. The research suggests women and men with cocaine dependence may possibly benefit a lot more from different cocaine treatment options.

There are differences in treatment outcomes for individuals having addictions that experience drug cravings caused by stress and people whose cravings are caused by drug cues. It’s necessary to know the biologic mechanisms which trigger these cravings.

Cocaine Dependence
Cocaine Dependence Differences in Men and Women

The study used functional magnetic resonance imaging scans of thirty people with cocaine dependence as well as thirty six control subjects that were recreational drinkers. Whilst having brain scans, the researchers then gave subjects personalized cues (events or situations) that the participants had said were personally stressful along with other cues involving alcohol or cocaine.

Not surprisingly, those with cocaine dependence exhibited greater activation in broad parts of the brain associated with addiction and motivation compared to the control subjects. However, patterns of activation between the groups differed considerably in women and men when given stress or drug cues.

The results indicate that women with cocaine dependence could possibly benefit from stress reduction therapies which specifically target these cravings. On the other hand, men with cocaine dependence could possibly get more benefit from aspects of cognitive behavioral therapy or 12-step programs according to the principles of Alcoholics Anonymous.

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